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Classic Hodgkin Lymphoma : Spleen

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Splenic Involvement in Hodgkin Lymphoma: Spleen involvement is suggested by palpable splenomegaly and can be confirmed by imaging studies such as fludeoxyglucose - positron emission tomography (FDG-PET) or CT. Findings on FDG-PET include diffuse uptake, solitary mass, multiple large nodules, or miliary lesions.

Spleens involved by Hodgkin lymphoma usually weigh > 400 grams. The disease may be focal; the spleen should therefore be carefully examined after thin slicing. Every suspicious focus should be submitted for histology.

Grossly, the nodules may be focal, large and few or numerous, small and scattered throughout the organ. The number of tumor nodules has prognostic implications and should be noted (more specifically, it should be mentioned whether there are five or more nodules).

The image shows classic Hodgkin lymphoma, nodular sclerosis, involving spleen.

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