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Hodgkin Lymphoma : Differential Diagnosis

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Classic Hodgkin Lymphoma - Differential Diagnosis: Many subtypes of non-Hodgkin lymphomas (NHL), reactive disorders, and even non-hematopoietic neoplasms can show overlapping histologic features with classic Hodgkin lymphoma (cHL). Some cases have hybrid morphologic and phenotypic features between large B-cell lymphomas and cHL and have been referred to as gray-zone lymphomas.

The differentiating features of cHL from some of the important NHLs are shown in the table above. For an excellent detailed discussion of the differential diagnosis of cHL, please refer to Hematopathology by E. S. Jaffe (see reference).

Abbreviations: CHL classic Hodgkin lymphoma; NLPHL nodular lymphocyte predominant Hodgkin lymphoma; THRLBCL T-cell/Histiocyte-rich large B-cell lymphoma; ALCL anaplastic large cell lymphoma; NS nodular sclerosis; LR lymphocyte-rich; LRCHL lymphocyte-rich classic Hodgkin lymphoma; MC mixed cellularity; RS Reed-Sternberg; FDC follicular dendritic cells; EBV Epstein-Barr virus.

Reference: Table adapted from Jaffe, E. S. et al (2017). Hematopathology - Second Edition. Philadelphia, PA. Elsevier.

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