Comments: Grossly, chromophobe renal cell carcinoma is usually a well-circumscribed solitary mass in the kidney as seen in this case. The cut surface may be yellow, beige, or brown with close resemblance to oncocytoma. A central scar is seen in this specimen. Case contributed by: Liang Cheng, MD, Dept. of Pathology, Indiana University School of Medicine, Indianapolis.
Comments: The central scar is more clearly seen in this close-up of previous image. Some tumors may show foci of necrosis, hemorrhage, cyst formation, calcification, or even ossification. Case contributed by: Liang Cheng, MD, Dept. of Pathology, Indiana University School of Medicine, Indianapolis.
Comments: Chromophobe renal cell carcinoma comprises about 5% of epithelial renal neoplasms. Microscopically, it is composed of variably-sized cells with abundant pale reticular or flocculent cytoplasm.
Comments: The nuclei are moderately sized and hyperchromatic. Bi- and multinucleated cells are not uncommon. Chromophobe RCC appears to have a better 5-yr disease-specific and progression-free survival than conventional (clear cell) RCC or papillary RCC. Am J Surg Pathol 2002 March; 26(3) 281-91.
