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1:
Urothelial Papilloma : Case 1
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Comments: Urothelial papilloma should be distinguished from papillary urothelial neoplasm of low malignant potential (WHO/ISUP Classification, 1998) (formerly Grade 1 (of 3) papillary transitional cell carcinoma, WHO Classification, 1973). This photomicrograph has all the classic features of urothelial papilloma described in the next few slides.
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2:
Urothelial Papilloma : Case 1
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Comments: Urothelial papilloma consists of papillary fronds containing delicate fibrovascular cores lined by less than 7 layers of cytologically and architecturally normal urothelium. Prominent cytoplasmic vacuoles are seen.
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3:
Urothelial Papilloma : Case 2
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Comments: Using criteria recommended by WHO, urothelial papilloma comprises less than 3% of papillary urothelial neoplasms. Usually, they are small solitary papillary lesions (less than 2 cm in size).
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5:
Urothelial Papilloma : Case 2
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Comments: Note the absence of cytologic atypia or mitotic figures. Some authors propose expanding the category of urothelial papilloma to include most WHO Grade 1 urothelial carcinoma – a proposal not favored by most pathologists.
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7:
Urothelial Papilloma : Case 3
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Comments: Again note cytologically and architecturally normal urothelium lining this papillary frond. Urothelial papilloma is considered to be a benign lesion with infrequent recurrences and exceedingly low risk of development of urothelial carcinoma. Cheng et al. Urothelial papilloma of the bladder. Cancer 1999; 86:2098-101
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