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1:
Seminoma : Gross Morphology
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Comments: The cut surface shows a cream-colored, soft, fleshy, multinodular tumor bulging from the surrounding testicular parenchyma. Note a satellite nodule on the lower left.
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2:
Seminoma : Gross Morphology
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Comments: The tumor consists of multiple soft pink-tan nodules. The firm whitish areas nearby showed extensive intratubular germ cell neoplasia.
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3:
Seminoma
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Comments: Diffuse sheets of tumor cells with clear cytoplasm separated by fibrous trabeculae containing lymphocytes.
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4:
Seminoma
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Comments: The lymphocytic infiltrate in the fibrous trabeculae separating tumor cells is more clearly seen here.
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5:
Seminoma : Lymphoid Infiltrate
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Comments: Note the lymphocytic infiltrate surrounding clusters of tumor cells creating a pseudoglandular appearance.
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6:
Seminoma
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Comments: The cytoplasm of seminoma cells is usually clear to lightly eosinophilic. The cytoplasmic clearing is due to glycogen content which can be demonstrated by PAS positivity. The nuclei are round to oval with granular chromatin and prominent nucleoli.
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7:
Seminoma : Lymphoid Reaction
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Comments: Lymphocytic infiltrate in fibrous trabeculae and perivascular spaces is seen in virtually all cases of classic seminoma. Occasional cases such as this one show florid lymphoid reaction with formation of germinal centers.
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8:
Seminoma : Interstitial Growth Pattern
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Comments: At the periphery of the tumor nodule, an interstitial growth pattern of seminoma cells may be seen with preservation of seminiferous tubules. The tubules seen here show intratubular germ cell neoplasia.
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9:
Seminoma : Interstitial Growth Pattern
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Comments: In this case of seminoma, the tumor cells infiltrate the interstitium between atrophic seminiferous tubules. The patient had history of cryptorchidism.
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10:
Seminoma : Syncytiotrophoblastic Cells
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Comments: Syncytiotrophoblastic giant cells are present in 10% to 20% of seminomas. In this image, two giant cells can be seen. They are usually randomly scattered in the tumor and not associated with cytotrophoblastic cells unlike choriocarcinoma. They are responsible for modest elevations of b-HCG seen in some seminomas.
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13:
Seminoma : Pagetoid Spread into Rete
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Comments: Rete testis showing pagetoid spread of intratubular germ cell neoplasia (ITGCN) from nearby tubules in this case of seminoma. Areas in the upper left are uninvolved and filled with proteinaceous fluid. The tubules in the lower right show pagetoid involvement by tumor cells.
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14:
Seminoma : Pagetoid Spread into Rete
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Comments: In one study, pagetoid spread of ITGCN to rete testis was seen in 28% of seminomas and in 49% of non-seminomatous germ cell tumors (Perry A, Wiley EL, Albores-Saavedra J. Hum Pathol. 1994 Nov; 25(11):1256-7. Another study reported this phenomenon in 14 of 47 cases (29.7%) of germ cell tumors. Lee AH, Theaker JM. Histopathology. 1995 Oct; 27(4):391-2.
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