| Webpathology.com

Genitourinary Tract Genitourinary Tract

Home \| About this Site \| Feedback \| Site Map		Monday, September 06, 2010

Prostate : Hyperplasia

Back to Prostate | Return to Genitourinary Tract

1: Basal Cell Hyperplasia in Prostate Needle Biopsy


	Comments: Basal cell hyperplasia is usually seen in the transition zone. Occasionally, it may be encountered in needle biopsies (which sample peripheral zone).

2: Basal Cell Hyperplasia - Higher Magnification


	Comments: The nuclei are ovoid or round with finely reticular chromatin and rare punctate nucleoli. The cytoplasm is pale eosinophilic or clear.

3: Basal Cell Hyperplasia with Prominent Nucleoli


	Comments: In rare instances, basal cell hyperplasia shows prominent nucleoli. This is referred to as atypical basal cell hyperplasia. In most cases, this is in response to inflammation nearby.

4: Atypical Adenomatous Hyperplasia in Needle Biopsy


	Comments: Atypical adenomatous hyperplasia (adenosis) - when seen in a needle biopsy - is one of the most challenging benign mimics of cancer. A partially sampled focus of cancer may be mistaken for AAH.

5: Atypical Adenomatous Hyperplasia - 34bE12 Immunostain


	Comments: The immunostain for high molecular weight cytokeratin 34bE12 nicely demonstrates the fragmented basal cell layer in this focus of AAH encountered in a needle biopsy.

6: Atypical Adenomatous Hyperplasia


	Comments: AAH encountered in a transurethral resection specimen.

7: Atypical Adenomatous Hyperplasia - 34bE12 Immunostain


	Comments: The immunostain for high molecular weight cytokeratin 34bE12 demonstrates fragmented basal cell layer in the previous focus of AAH.

8: Atypical Adenomatous Hyperplasia


	Comments: Note the lack of cytologic atypia in AAH at high magnification.

9: Post-atrophic Hyperplasia


	Comments: Clusters of atrophic prostatic acini with proliferative changes. At low magnification, it may be mistaken for adenocarcinoma; however, they lack cytologic features of cancer such as prominent nucleoli.

10: Post-atrophic Hyperplasia - Higher Magnification


	Comments: This case is not difficult to distinguish from prostatic adenocarcinoma. In challenging cases, the immunostain for high molecular weight cytokeratin is invaluable (see next image). Post-atrophic hyperplasia: A histologic mimic of adenocarcinoma. Am J Surg Pathol 19(9): 1068-1076, 1995 .

11: Post-atrophic Hyperplasia - 34bE12 Immunostain


	Comments: The majority of the glands show a prominent basal cell layer with the immunostain for high molecular weight cytokeratin 34bE12.

12: Clear Cell Cribriform Hyperplasia


	Comments: Lobular clusters of glands with cribriform architecture.

13: Clear Cell Cribriform Hyperplasia


	Comments: The glandular clusters have punched out lumens. The cytoplasm is clear or pale eosinophilic. The nuclei are uniform and lack nucleoli. Basal cells can be clearly seen.

14: Stromal Hyperplasia with Atypia


	Comments: Large atypical cells with hyperchromatic nuclei containing intranuclear vacuoles are interspersed between benign glands. Prostatic stromal hyperplasia with atypia: A study of 11 cases. Journal of Urologic Pathology, 6:15-26, 1997 .