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3:
Basal Cell Hyperplasia with Prominent Nucleoli
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Comments: In rare instances, basal cell hyperplasia shows prominent nucleoli. This is referred to as atypical basal cell hyperplasia. In most cases, this is in response to inflammation nearby.
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4:
Atypical Adenomatous Hyperplasia in Needle Biopsy
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Comments: Atypical adenomatous hyperplasia (adenosis) - when seen in a needle biopsy - is one of the most challenging benign mimics of cancer. A partially sampled focus of cancer may be mistaken for AAH.
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9:
Post-atrophic Hyperplasia
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Comments: Clusters of atrophic prostatic acini with proliferative changes. At low magnification, it may be mistaken for adenocarcinoma; however, they lack cytologic features of cancer such as prominent nucleoli.
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10:
Post-atrophic Hyperplasia - Higher Magnification
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Comments: This case is not difficult to distinguish from prostatic adenocarcinoma. In challenging cases, the immunostain for high molecular weight cytokeratin is invaluable (see next image). Post-atrophic hyperplasia: A histologic mimic of adenocarcinoma. Am J Surg Pathol 19(9): 1068-1076, 1995 .
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13:
Clear Cell Cribriform Hyperplasia
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Comments: The glandular clusters have punched out lumens. The cytoplasm is clear or pale eosinophilic. The nuclei are uniform and lack nucleoli. Basal cells can be clearly seen.
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14:
Stromal Hyperplasia with Atypia
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Comments: Large atypical cells with hyperchromatic nuclei containing intranuclear vacuoles are interspersed between benign glands. Prostatic stromal hyperplasia with atypia: A study of 11 cases. Journal of Urologic Pathology, 6:15-26, 1997 .
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15:
Prostate - Nodular Hyperplasia
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Comments: Hyperplasia of the median lobe of the prostate produces a polypoid mass that protrudes in the bladder lumen.
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