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1:
Prostate : Acute Inflammation
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Comments: There is marked neutrophilic infiltrate within and around glands. Some glands are partially destroyed. The term ‘prostatitis’ is a clinical term and perhaps should not be used in pathology reports. A pathologist should only comment upon the presence or absence of inflammation.
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2:
Prostate : Non-specific Granulomatous Inflammation
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Comments: A dense inflammatory infiltrate has replaced glandular epithelium which has been largely destroyed. Some cases of granulomatous prostatitis may closely mimic high-grade cancer. Small foci of cancer adjacent to foci of inflammation may sometimes be overlooked.
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4:
Prostate : Post-BCG Granulomatous Inflammation
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Comments: This patient received intravesical BCG therapy for non-invasive papillary urothelial carcinoma. The resultant inflammation in the prostate caused PSA elevation. A prostate biopsy showed several well-formed non-caseating granulomas as seen here.
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6:
Prostate : Post-biopsy granuloma
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Comments: An area of fibrinoid necrosis walled off by a cuff of histiocytes is seen in this prostate biopsy. This is most likely in response to a previous biopsy.
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7:
Prostate : Malakoplakia
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Comments: All the classic features of malakoplakia are present. The prostatic glands are replaced by sheets of histiocytes, lymphocytes, and plasma cells. Several targetoid Michelis-Gutmann bodies are seen.
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8:
Prostate : Xanthoma
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Comments: Usually an incidental finding in older men. Clusters of lipid-laden macrophages are seen. Differentiation from ‘hypernephroid” pattern of prostate cancer may be difficult. Xanthoma usually has inflammation nearby. The cells in question are negative for PSA and PAP and strongly stain for CD68.
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9:
Prostate : Xanthoma (CD68 Immunostain)
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Comments: In difficult cases, strong immunoreactivity for CD68 can help differentiate xanthoma from high-grade prostate carcinoma (same case as previous image)
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