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Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma:
Hibernoma: Hibernomas are composed of polygonal cells with varying degrees of differentiation. Some cells show eosinophilic granular cytoplasm; others are multivacuolated with numerous small lipid droplets surrounding a central nucleus. Unlike the lipoblasts, there is no indentation or scalloping of the nuclear contour. Mature adipocytes may be admixed within the tumor.
Hibernoma: Hibernomas are composed of polygonal cells with varying degrees of differentiation. Some cells show eosinophilic granular cytoplasm; others are multivacuolated with numerous small lipid droplets surrounding a central nucleus. Unlike the lipoblasts, there is no indentation or scalloping of the nuclear contour. Mature adipocytes may be admixed within the tumor.