Large Cell NE Carcinoma : Molecular Genetics

Neuroendocrine tumors of the lung are subdivided into 4 major categories: 1) Small cell lung carcinoma (SCLC); 2) Large cell neuroendocrine carcinoma (LCNEC); 3) Atypical carcinoid (AC); and 4) Typical carcinoid (TC). SCLC and LCNEC are high-grade malignant tumors, AC is intermediate-grade, and TC is considered low-grade malignant tumor. TC and AC are more closely related to each other than to SCLC or LCNEC. About 40% of patients with TC or AC are non-smokers. TC and AC can occur in patients with MEN type I syndrome and about 40% of sporadic cases carry MEN I mutations. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia is considered to be a precursor lesion for both TC and AC. SCLC and LCNEC are strongly linked with cigarette smoking and are rarely seen in non-smokers. There is no known precursor lesion. They are driven by inactivating mutations in TP53 (100% of cases) and RB genes (100% of cases) and have no association with MEN I syndrome. They carry the characteristic tobacco-smoking related carcinogenic signature – large number of mutations and high fraction of G to T transversions in methylated CpG dinucleotides – caused by polycyclic aromatic hydrocarbons in tobacco smoke.