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References:
1. Unni KK & Inwards CY (2010). Dahlin's Bone Tumors. 6th Edition. Wolters Kluwer/Lippincott Williams & Wilkins.
2. Nielsen, GP & Rosenberg, AE (2021). Diagnostic Pathology: Bone - 3rd Edition. Philadelphia, PA. Elsevier.
3. Bullough PG (2004). Orthopedic Pathology. 4th Edition. Mosby.
4. Soft Tissue and Bone Tumours. WHO Classification of Tumours (WHO Fascicle). 5th Edition 2020.
5. Tuck SP et al. Adult Paget's Disease of Bone: A Review. Rheumatology 2017;56:2050-2059.
6. Ralston SH et al. Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline. Journal of Bone and Mineral Research 2019; Vol. 34, No. 4, pp 579-604.
7. Ralston SH & Layfield R. Pathogenesis of Paget Disease of Bone. Calcif Tissue Int (2012) 91:97-113.
8. Zhang N et al. Pros and Cons of Denosumab Treatment for Osteoporosis and Implication for RANKL Aptamer Therapy. Front. Cell Dev. Biol. May 2020, 8:325.

About this image: Fibroblastic Osteosarcoma arising in the setting of Paget disease of bone (PDB). The image shows sclerotic phase of PDB on the right and highly atypical spindle cell proliferation on the left (same case as the previous image).

Image 46 of 48