Image Description
Higher magnification of chondroid area in a chondroid chordoma. The neoplastic cells are present in lacunar-like spaces embedded within basophilic matrix, producing a strong resemblance to low-grade chondrosarcoma.
An immunohistochemical panel of brachyury, cytokeratin, EMA, and S100 is sufficient in resolving most cases. Chordomas are positive for all four markers, where as conventional chondrosarcomas are brachyury-, cytokerain-, EMA- and S100+. Extraskeletal myxoid chondrosarcomas are brachyury-, cytokeratin-, EMA+ and S100-. In addition, they show NR4A3 rearrangement.
An immunohistochemical panel of brachyury, cytokeratin, EMA, and S100 is sufficient in resolving most cases. Chordomas are positive for all four markers, where as conventional chondrosarcomas are brachyury-, cytokerain-, EMA- and S100+. Extraskeletal myxoid chondrosarcomas are brachyury-, cytokeratin-, EMA+ and S100-. In addition, they show NR4A3 rearrangement.