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Chordoma - Immunophenotype: Chordomas express brachyury, cytokeratin AE1/AE3, EMA, S100 protein, SOX9 and vimentin. CEA and GFAP are variably positive. With GFAP, reactivity is usually seen with polyclonal antibodies and less often with monoclonal antibodies. Poorly-differentiated chordomas show loss of SMARCB1/INI1 staining.
Cytokeratin AE1/AE3 detects cytokeratins 1-8, 10, 14-16, and 19.
Cytokeratin AE1/AE3 detects cytokeratins 1-8, 10, 14-16, and 19.