Desmoplastic Infantile Ganglioglioma

A gemistocyte-like cell can be seen in the center of the image. Such cells stain with GFAP. Neuronal markers (synaptophysin, chromogranin, neurofilament) are positive in the ganglion cells which may be inconspicuous on routine H&E stain. Despite their large size, the overall prognosis is good in most patients. The treatment of choice is surgical resection. Dural attachment may make complete resection difficult. Adjunctive chemotherapy may be given in such cases.