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Pulmonary Coccidioidomycosis: In routinely-stained tissue sections, the diagnostic feature is the presence of mature and immature spherules. The background consists of necrotizing and non-necrotizing granulomas and a mixed inflammatory infiltrate of epithelioid histiocytes, neutrophils, eosinophils, lymphoplasmacytic cells, and multinucleated giant cells.
Mature spherules are thick-walled, doubly refractile bodies measuring 60-100 μm in diameter and contain multiple endospores measuring 2-5 μm. In addition to mature and immature spherules, mycelia may be found in rare circumstances if the patient develops bronchopulmonary fistula or aerated pulmonary cavities.
Mature spherules are thick-walled, doubly refractile bodies measuring 60-100 μm in diameter and contain multiple endospores measuring 2-5 μm. In addition to mature and immature spherules, mycelia may be found in rare circumstances if the patient develops bronchopulmonary fistula or aerated pulmonary cavities.