Image Description
Epidermodysplasia verruciformis (EV) is a rare genodermatosis (genetic disorder with cutaneous expression) that results in abnormal susceptibility to cutaneous HPV infections (caused mostly by HPV5 and HPV8 of the beta genus) and a higher risk of non-melanoma skin cancers. It has also been referred to as Lewandowsky-Lutz syndrome. The transmission is autosomal recessive in most patients.
The clinical manifestations of EV become apparent during infancy or childhood and consist of hypo- or hyperpigmented, scaly, macular plane warts on trunk, face, neck, arms, dorsal hands and feet (sun-exposed areas).
The histologic features of EV consist of acanthosis, hyperkeratosis, and enlarged keratinocytes with bluish-gray cytoplasm in the upper layers of epidermis.
Additional images and discussion of epidermodysplasia verruciformis are here
The clinical manifestations of EV become apparent during infancy or childhood and consist of hypo- or hyperpigmented, scaly, macular plane warts on trunk, face, neck, arms, dorsal hands and feet (sun-exposed areas).
The histologic features of EV consist of acanthosis, hyperkeratosis, and enlarged keratinocytes with bluish-gray cytoplasm in the upper layers of epidermis.
Additional images and discussion of epidermodysplasia verruciformis are here