Systemic Mastocytosis : Liver - CD117

Liver in Systemic Mastocytosis (SM): As in other locations such as bone marrow, immunostains for CD25, CD117, and tryptase are helpful in assessing mast cell burden in cases of systemic mastocytosis.

This image shows periportal as well as intrasinusoidal infiltrates of CD117-positive mast cells.