Image Description
Darier sign is an important diagnostic feature of mastocytosis and refers to the wheal and flare reaction seen following stroking, rubbing, or scratching a lesion. It is due to degranulation of mast cells and appears within a few minutes following physical stimulation.
Image source: Broesby-Olsen, S. et al. Multidisciplinary Management of Mastocytosis : Nordic Expert Group Consensus. Acta Derm Venereol 2016; doi: 10.2340/00015555-2325; Used under Creative Commons Attribution NonCommercial 4.0 International License
Image source: Broesby-Olsen, S. et al. Multidisciplinary Management of Mastocytosis : Nordic Expert Group Consensus. Acta Derm Venereol 2016; doi: 10.2340/00015555-2325; Used under Creative Commons Attribution NonCommercial 4.0 International License