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Clinical Features: Primary cutaneous follicle center lymphoma (PCFCL) arises in middle-aged adults (50-60 years old) and shows a slight male predominance. The disease is limited to skin by definition. It presents as painless, non-pruritic, erythematous or violaceous papules, firm plaques or tumor nodules, usually on scalp, forehead, or the trunk, and occasionally on legs. Ulceration is rare.
The lesions are solitary or multiple and grouped together in a localized area (60% of cases). True multifocal disease is rare and is seen in about 15% of cases. In the absence of treatment, the lesions can attain large size, but rarely spread to extracutaneous sites.
The lesions are solitary or multiple and grouped together in a localized area (60% of cases). True multifocal disease is rare and is seen in about 15% of cases. In the absence of treatment, the lesions can attain large size, but rarely spread to extracutaneous sites.