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A skeletal survey (i.e. a series of radiographs systematically performed to cover the entire skeleton) is essential in making the diagnosis of plasma cell myeloma, assessing the response to treatment, as well as pre-empting mechanical complications such as pathologic fractures. Computed tomography (CT) scans and magnetic resonance imaging (MRI) are more sensitive than plain radiographs in detecting small bone lesions as well as in identifying extramedullary plasmacytomas.

This CT of spine (Sagittal bone window) shows extensive lytic lesions. The patient had plasma cell myeloma. Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org. From the case rID: 7682

Image 10 of 66