Image Description
Morphology: Bladder MALT lymphoma is composed of medium-sized neoplastic marginal zone B-cells with moderate to abundant pale cytoplasm, slightly irregular medium-sized nuclei with dispersed chromatin, and inconspicuous nucleoli.
Discrete large transformed cells with morphology of centroblasts or immunoblasts are usually present in variable numbers. This image shows 2-3 such cells. If they form solid aggregates, nodules or confluent sheets, a diagnosis of diffuse large B-cell lymphoma should be considered.
References:
1. Jaffe, E. S. et al (2017). Hematopathology - Second Edition. Philadelphia, PA. Elsevier.
2. Holger Moch, Peter A. Humphrey, Thomas M. Ulbright, Victor E. Reuter (2016). WHO Classification of the Tumors of the Urinary System and Male Genital Organs, 4th Edition; IARC, Lyon, France.
3. Swerdlow, S. H. et al (2017). WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues, Revised 4th Edition; IARC, Lyon, France.
4. Cheng, L., MacLennan G. T., & Bostwick, D. G. (2020). Urologic Surgical Pathology - 4th Edition. Philadelphia, PA. Elsevier.
Discrete large transformed cells with morphology of centroblasts or immunoblasts are usually present in variable numbers. This image shows 2-3 such cells. If they form solid aggregates, nodules or confluent sheets, a diagnosis of diffuse large B-cell lymphoma should be considered.
References:
1. Jaffe, E. S. et al (2017). Hematopathology - Second Edition. Philadelphia, PA. Elsevier.
2. Holger Moch, Peter A. Humphrey, Thomas M. Ulbright, Victor E. Reuter (2016). WHO Classification of the Tumors of the Urinary System and Male Genital Organs, 4th Edition; IARC, Lyon, France.
3. Swerdlow, S. H. et al (2017). WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues, Revised 4th Edition; IARC, Lyon, France.
4. Cheng, L., MacLennan G. T., & Bostwick, D. G. (2020). Urologic Surgical Pathology - 4th Edition. Philadelphia, PA. Elsevier.