Image Description
The skin lesions of cutaneous Rosai-Dorfman disease show a dense cellular infiltrate of histiocytes and lymphocytes in the dermis and subcutis. In addition, there may be plasma cells, neutrophils, and eosinophils. The infiltrate may have a nodular pattern. Some cases show stromal fibrosis with a storiform pattern.
Emperipolesis is not conspicuous. Ulceration, necrosis, cytologic atypia, increased mitotic activity, and granulomas are not present. Rare cases may show reactive lymphoid follicles.
Emperipolesis is not conspicuous. Ulceration, necrosis, cytologic atypia, increased mitotic activity, and granulomas are not present. Rare cases may show reactive lymphoid follicles.