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The diagnosis of silicone lymphadenopathy is straightforward.The patient typically has history of a reconstructive, cosmetic, or orthopedic procedure with an implant and presents with regional lymphadenopathy.
The histologic findings, as shown in the previous two slides, include partial lymph node involvement, empty-appearing vacuoles of various sizes, aggregates of histiocytes with frothy or foamy cytoplasm, and foreign body giant cells which often contain Asteroid bodies.
If needed, silicone can be conclusively identified in tissue samples by a variety of techniques, including infrared spectroscopy, gas chromatography/mass spectroscopy, and energy-dispersive X-ray elemental analysis.
The histologic findings, as shown in the previous two slides, include partial lymph node involvement, empty-appearing vacuoles of various sizes, aggregates of histiocytes with frothy or foamy cytoplasm, and foreign body giant cells which often contain Asteroid bodies.
If needed, silicone can be conclusively identified in tissue samples by a variety of techniques, including infrared spectroscopy, gas chromatography/mass spectroscopy, and energy-dispersive X-ray elemental analysis.