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The differential diagnosis of Whipple disease includes mycobacterium tuberculosis granulomas (PAS-negative; Acid-fast positive) and mycobacterium avium-intracellulare granulomas (PAS-positive and Acid-fast positive), lysosomal storage diseases (Gaucher, Fabry), and abdominal lymphomas.

The image shows aggregates of foamy macrophages in a mesenteric lymph node in Whipple disease.

Image 39 of 69