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Microscopic Features of Sarcoidosis: The cardinal histologic finding in sarcoid lymphadenopathy is the presence of numerous confluent non-necrotizing epithelioid granulomas replacing normal nodal parenchyma. A necrotizing variant of sarcoidosis is sometimes seen in extranodal sites.
The granulomas are discrete compact aggregates of epithelioid histiocytes with abundant pink cytoplasm, surrounded by a rim of CD4+ T-cells. Over time, the granulomas are eventually replaced by hyalinized scars.
The granulomas are discrete compact aggregates of epithelioid histiocytes with abundant pink cytoplasm, surrounded by a rim of CD4+ T-cells. Over time, the granulomas are eventually replaced by hyalinized scars.