Sclerosing Polycystic Adenosis

Higher magnification showing a combination of apocrine and mucoid cells with zymogen-like granules. The clinical behavior is generally benign. However, some cases show enough atypia to consider the diagnosis of a low-grade malignant neoplasm. Some studies have shown that the lesion is clonal, further generating controversy as to its true nature. Image courtesy of: Dr. Simon Chiosea, Associate Professor of Pathology, Univ. of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

References:1. Sclerosing polycystic adenosis of major salivary glands. A clinicopathologic analysis of nine cases.Smith BC, Ellis GL, Slater LJ, Foss RD. Am J Surg Pathol. 1996