Hidradenoma Papilliferum : Microscopic
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Microscopic Features of Hidradenoma Papilliferum (continued): Cytologic atypia is absent or mild and the mitotic activity may be increased. Focal oxyphil metaplasia with increased cytologic atypia may be seen. Diastase-resistant PAS-positive cytoplasmic granules are frequently present.
Some cases show prominent apocrine differentiation in the surface glandular cells. In the surrounding stroma, there may be residual anogenital mammary-like glands. Areas resembling sclerosing adenosis and ductal hyperplasia of breast may be seen. The presence of fibrosis may impart an infiltrative appearance to the glandular structures mimicking infiltrative carcinoma.
Some cases show prominent apocrine differentiation in the surface glandular cells. In the surrounding stroma, there may be residual anogenital mammary-like glands. Areas resembling sclerosing adenosis and ductal hyperplasia of breast may be seen. The presence of fibrosis may impart an infiltrative appearance to the glandular structures mimicking infiltrative carcinoma.