Image Description
Differential Diagnosis of Ovarian Steroid Cell Tumor, NOS: Steroid cell tumors of the ovary are diagnosed easily in most cases; however, their subclassification can be challenging. Following entities should be considered in the differential diagnosis of steroid cell tumor (SCT), NOS.
Leydig Cell Tumor (LCT): The distinction of LCT from SCT, NOS is important since LCT is an indolent tumor whereas 30-40% of SCT, NOS are malignant. The diagnosis of LCT is supported by its hilus location and the presence of Reinke crystals.
Luteinized Thecoma: It has a prominent component of thecomatous spindle cell fibers as well as pericellular reticulin fibers.
Luteinized Granulosa Cell Tumor (GCT): GCT is rarely completely luteinized. Areas with more typical granulosa cell differentiation are usually present. GCT is more estrinizing and is positive for FOXL2 which is often negative in SCT, NOS. (continued in the next image).
Leydig Cell Tumor (LCT): The distinction of LCT from SCT, NOS is important since LCT is an indolent tumor whereas 30-40% of SCT, NOS are malignant. The diagnosis of LCT is supported by its hilus location and the presence of Reinke crystals.
Luteinized Thecoma: It has a prominent component of thecomatous spindle cell fibers as well as pericellular reticulin fibers.
Luteinized Granulosa Cell Tumor (GCT): GCT is rarely completely luteinized. Areas with more typical granulosa cell differentiation are usually present. GCT is more estrinizing and is positive for FOXL2 which is often negative in SCT, NOS. (continued in the next image).