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Introduction: Gonadoblastoma is an uncommon tumor composed of an admixture of dysgerminoma-like primitive germ cells and sex cord cells resembling Sertoli and granulosa cells. It almost always occurs in children or young adults with gonadal dysgenesis. About 80% of patients are phenotypic females; the rest are phenotypic males or have ambiguous genitalia.
Most cases are discovered incidentally during the evaluation of a young patient with intersex features and primary or secondary amenorrhea. Gonadoblastoma is benign but it is considered to be a precursor lesion for invasive germ cell tumor (GCT) of dysgenetic gonads.
About this image: High-power view of a gonadoblastoma showing the dual cell populations of germ cells (larger cells with clear cytoplasm) and smaller sex-cord cells. Numerous round spaces filled with basement membrane material are also present.
Most cases are discovered incidentally during the evaluation of a young patient with intersex features and primary or secondary amenorrhea. Gonadoblastoma is benign but it is considered to be a precursor lesion for invasive germ cell tumor (GCT) of dysgenetic gonads.
About this image: High-power view of a gonadoblastoma showing the dual cell populations of germ cells (larger cells with clear cytoplasm) and smaller sex-cord cells. Numerous round spaces filled with basement membrane material are also present.