Dysgerminoma : Genetics
Image Description
Like seminomas, dysgerminomas show chromosome 12p abnormalities in the form of isochromosome 12p or 12p amplification in 80% of cases. About 25-50% of dysgerminomas have point mutations in c-kit which encodes for KIT - a tyrosine kinase receptor. The mutations are localized to exon 17, codon 816 and do not confer susceptibility to tyrosine kinase inhibitor imatinib. KIT mutations do not correlate with KIT protein expression. About one-third of cases show KIT amplification.
The image shows clusters of polygonal tumor cells with clear or lightly eosinophilic cytoplasm separated by delicate fibrous septa.
The image shows clusters of polygonal tumor cells with clear or lightly eosinophilic cytoplasm separated by delicate fibrous septa.