Image Description
Immunohistochemistry of Adult Granulosa Cell Tumors of the Testis: The tumor cells are immunoreactive for inhibin (shown here), vimentin, calretinin, and CD99. They may be positive for melan A, FOXL2, SMA, and S-100 protein. There may be paranuclear dot-like positivity for low molecular weight cytokeratins (CK8, CK18). Nuclear beta-catenin and EMA are negative.
FOXL2 and SF1 are highly sensitive but not specific as they tend to be positive in other sex cord-stromal tumors as well. FOXL2 mutation is seen in adult granulosa cell tumors (considerably more common in ovarian than in testicular).
FOXL2 and SF1 are highly sensitive but not specific as they tend to be positive in other sex cord-stromal tumors as well. FOXL2 mutation is seen in adult granulosa cell tumors (considerably more common in ovarian than in testicular).