Adult Granulosa Cell Tumor : Clinical & Gross
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
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Introduction: Granulosa cell tumor of the testis may occur in adults (adult type) or in infants (juvenule type). Adult granulosa cell tumor (AGCT) of the testis is an uncommon tumor that is composed of cells closely resembling granulosa cells of the Graafian follicle. It is similar morphologically to its counterpart in the ovary.
Clinical Features: It makes up < 0.5% of all sex cord-stromal tumors of the testis. It is seen over a wide age range, with the median age of 40 years at diagnosis. The patients usually present with a testicular mass. Rare cases show hormonal manifestations such as gynecomastia. Metastases are uncommon and occur to retroperitoneal lymph node, liver, lungs, and bone.
Gross Morphology: AGCT is usually solitary and unilateral. The size ranges from 0.5 to 6 cm. The tumor is usually solid, well-circumscribed, and yellow-tan in color. Uncommonly, there is a prominent cystic component (as seen in this case). Hemorrhage and necrosis are seen more frequently in malignant cases.
Clinical Features: It makes up < 0.5% of all sex cord-stromal tumors of the testis. It is seen over a wide age range, with the median age of 40 years at diagnosis. The patients usually present with a testicular mass. Rare cases show hormonal manifestations such as gynecomastia. Metastases are uncommon and occur to retroperitoneal lymph node, liver, lungs, and bone.
Gross Morphology: AGCT is usually solitary and unilateral. The size ranges from 0.5 to 6 cm. The tumor is usually solid, well-circumscribed, and yellow-tan in color. Uncommonly, there is a prominent cystic component (as seen in this case). Hemorrhage and necrosis are seen more frequently in malignant cases.