Sclerosing Sertoli Cell Tumor
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
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Some cases of Sertoli cell tumor (SCT) have prominent hyaline fibrosis. The cellular component, which makes up less than 50% of the tumor, consists of compressed cords, trabeculae, small nests, and solid tubules in dense collagenous stroma.
This so-called "sclerosing Sertoli cell tumor" is now considered to be a morphologic variant of SCT rather than a separate entity. Like Sertoli cell tumor, NOS, the sclerotic variant also shows frequent mutations in CTNNB1 gene and nuclear positivity for beta-catenin. The clinical features are similar in both variants; however, the sclerotic variant appears to have a slightly better prognosis.
This so-called "sclerosing Sertoli cell tumor" is now considered to be a morphologic variant of SCT rather than a separate entity. Like Sertoli cell tumor, NOS, the sclerotic variant also shows frequent mutations in CTNNB1 gene and nuclear positivity for beta-catenin. The clinical features are similar in both variants; however, the sclerotic variant appears to have a slightly better prognosis.