Leydig Cell Tumor : STAR Antibody
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
Image Description
Steroidogenic acute regulatory protein (STAR) encoded by the STAR gene plays a key role in acute regulation of steroid hormone synthesis. It catalyzes conversion of cholesterol to pregnenolone. STAR is synthesized primarily by steroid-producing cells, including Leydig cells of testis, theca cells and luteal cells of the ovaries, and adrenal cortical cells.
STAR is a sensitive and a specific marker of Leydig cell tumor. It is available as a rabbit monoclonal antibody and is useful in differentiating sex cord-stromal tumors from the germ cell tumors of the testis. The image shows strong immunoreactivity for STAR in adrenal tissue.
Image courtesy of: Bio Sb Inc.; used with permission.
STAR is a sensitive and a specific marker of Leydig cell tumor. It is available as a rabbit monoclonal antibody and is useful in differentiating sex cord-stromal tumors from the germ cell tumors of the testis. The image shows strong immunoreactivity for STAR in adrenal tissue.
Image courtesy of: Bio Sb Inc.; used with permission.