Embryonal CA : Solid pattern vs Seminoma
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
Image Description
Solid pattern of embryonal carcinoma may mimic seminoma. Seminoma usually have less cytologic atypia and more distinct cytoplasmic borders. In addition, seminomas are negative for CD30; negative or only focally positive for cytokeratin; and positive for CD117. Embryonal carcinoma usually have reverse immunohistochemical profile (CD30+, cytokeratin +, CD117 neg).