Germ Cell Neoplasia in situ : OCT3/4

Section Editor: Dharam M. Ramnani, MD

Virginia Urology, Richmond, VA, USA

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OCT3/4 is a transcription factor that maintains pluripotency in embryonic stem cells and germ cells. It is a sensitive marker for germ cell neoplasia in situ (GCNIS). OCT3/4 shows predominantly nuclear staining pattern in GCNIS.
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