Germ Cell Neoplasia in situ : PLAP
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
Image Description
Immunoreactivity for Placenta-like Alkaline Phosphatase (PLAP) with cytoplasmic membrane staining and some cytoplasmic staining is a quite sensitive and a specific marker for germ cell neoplasia in situ (GCNIS). Normal germ cells and Sertoli cells are negative for PLAP.