GCNIS : Pagetoid Spread to Rete Testis
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
Image Description
Rete testis showing pagetoid spread of germ cell neoplasia in situ (GCNIS) from nearby tubules. The invasive component in this case was a seminoma. In one study, pagetoid spread of GCNIS to rete testis was seen in 28% of seminomas and in 49% of non-seminomatous germ cell tumors (Perry A, Wiley EL, Albores-Saavedra J. Hum Pathol. 1994 Nov; 25(11):1256-7.) Another study reported this phenomenon in 14 of 47 cases (29.7%) of germ cell tumors. Lee AH, Theaker JM. Histopathology. 1995 Oct; 27(4):391-2.