Image Description
When evaluated with immunohistochemical markers, neuroendocrine differentiation is seen in a high proportion of prostatic adenocarcinomas (between 30% to 100%). In about 10% of cases, it can be recognized on routine H&E stains due to the presence of large eosinophilic granules in the cytoplasm. The image shows a cluster of such cells in Gleason score 4+4=8 adenocarcinoma.