Central Zone Histology vs High-grade PIN
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
Image Description
The image shows glands of central zone at the base of the prostate which mimic high-grade PIN architecturally. There is nuclear crowding and pseudostratification with tufted, papillary and even cribriform areas within the glands. Central zone glands may sometimes be seen at the end of a prostate biopsy core admixed with smooth muscle of bladder neck. They lack nuclear enlargement and hyperchromasia and don't have prominent nucleoli.