Aberrant p63 expression in Prostate Cancer
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
Image Description
Aberrant expression of p63 may be seen in rare cases of prostate cancer. The image shows immunostaining with PIN4 cocktail (CK5/14, p63, AMACR). The smaller glands are clearly infiltrating in between larger benign glands which show a continuous basal cell layer. p63 staining in the smaller glands is within the tumor cells and not in a basal cell distribution. Both the cancer glands as well as the benign glands show racemase positivity (red chromogen).