Post-atrophic Hyperplasia - 34bE12 Immunostain

The distinction of post-atrophic hyperplasia from adenocarcinoma usually does not pose a diagnostic challenge. In rare cases with somewhat overlapping features, the immunostains for basal-cell specific markers can help. The image shows strong staining of basal cells with high molecular weight cytokeratin in the entire focus. In adenocarcinoma, the basal cell layer would be completely absent.