Atrophy - 34bE12 Immunostain
Section Editor: Dharam M. Ramnani, MD
Virginia Urology, Richmond, VA, USA
Image Description
The immunostain for high molecular weight cytokeratin can be helpful in distinguishing between atrophy (fragmented basal cell layer) from atrophic variant of prostatic adenocarcinoma (no basal cell layer). Caution should be exercised in diagnosing cancer in atrophic-appearing glands solely on the basis of absence of basal cell layer with immunostains in small biopsy specimens.