Section Editor: Dharam M. Ramnani, MD

Virginia Urology, Richmond, VA, USA

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Recent demonstration of anaplastic lymphoma kinase (ALK) by immunohistochemistry in majority of cases supports the view that inflammatory myofibroblastic tumor is a neoplastic process. Besides ALK, other markers frequently expressed in IMTs include cytokeratin, actin, desmin, and p53. They are negative for S100, CD34, and CD117.

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