Autosomal Dominant Polycystic Kidney: Clinical Features - 3

Clinical Features - 3 (continued from the previous image): The clinical presentation in autosomal dominant polycystic kidney disease usually consists of chronic flank pain, gross hematuria, polyuria, symptoms related to hypertension, urinary tract infections (which may progress to perinephric abscess), and renal calculi. About 20%-30% of patients develop renal calculi, usually uric acid stones. Enlarged kidney may produce a palpable abdominal mass. Hemorrhage into a cyst (shown in this image) and passage of blood clots may produce acute abdominal pain. Over time, the relentless dilation of the cysts destroys renal cortex and medulla bilaterally, ultimately leading to renal failure. The disease progresses more rapidly in blacks, especially if they have sickle cell trait.