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The main differential diagnostic considerations include undifferentiated gastric carcinoma, Burkitt lymphoma, and melanoma. Evaluation with lymphoid, epithelial, and melanocytic markers can help confirm the diagnosis. The prognosis of gastric diffuse large B-cell lymphoma depends on stage at presentation and on factors such as CD10 immunoreactivity. Overall 5-yr disease-free survival rate is much better than gastric carcinoma and is around 60%.