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High-grade mucinous cystic neoplasms (MCNs) frequently have solid areas, mural nodules, or papillary projections. There are areas with complex arborizing papillary or cribriform architecture, papillae without fibrovascular cores, luminal necrosis, nuclear hyperchromasia and pleomorphism, nuclear stratification, loss of polarity, prominent nucleoli, and frequent mitoses.
In a large study of 163 MCNs, 82.5% were low-grade, 5.5% were high-grade, and 12% had invasive carcinoma.
In a large study of 163 MCNs, 82.5% were low-grade, 5.5% were high-grade, and 12% had invasive carcinoma.