Fibrolamellar Carcinoma of Liver
Image Description
High magnification of FLC reveals clusters of large, polygonal tumor cells with large nuclei, prominent nucleoli, and abundant granular eosinophilic cytoplasm. The tumor cells often contain hyaline eosinophilic d-PAS+ globules (C-reactive protein, fibrinogen, alpha-1 antitrypsin) and "pale bodies" (fibrinogen, albumin), as seen here.