Fibrolamellar Carcinoma of Liver

Fibrolamellar carcinoma typically occurs in non-cirrhotic liver in young adults (mean age, 26 years) and is more common in females than males. The etiopathogenesis of this variant is unknown. Due to its resectability and the absence of cirrhosis, FLC may confer a better prognosis than conventional HCC. Like conventional HCC, FLC may be solitary or multiple. Macroscopically, it is well-circumscribed, nodular, and yellow/brown with extensive fibrosis. A central fibrous scar, when present, resembles that of focal nodular hyperplasia.