Hepatocellular Carcinoma - Pseudoglandular (Acinar) Pattern

The WHO describes several HCC histologic patterns, including trabecular (most common), acinar, solid, and scirrhous. Predominantly trabecular (sinusoidal) pattern HCC may also contain acinar (pseudoglandular) areas, as seen here, and should not be mistaken for an adenocarcinoma. The tumor cells recapitulate native hepatocytes, with round to oval nuclei and abundant granular eosinophilic cytoplasm. Note the prominent endothelial cell wrapping around tumor cell nests and trabeculae - a characteristic feature of HCC.