Focal Nodular Hyperplasia : Additional Image

The hepatocytes in focal nodular hyperplasia are relatively uniform with variable amounts of cytoplasmic glycogen, lipid (as seen here), bile, lipofuscin, iron pigment, or Mallory bodies. Occasionally, there is focal cytologic atypia, with enlarged nuclei, mild hyperchromasia, and conspicuous nucleoli. Mitotic activity is extremely rare and, if present, suggests the possibility of hepatocellular carcinoma. The center of this image shows a thick fibrous band with prominent ductular reaction.